Toxicity and application of high-purity iodomethane


Release time:

2020-10-29

Iodomethane is often used as the raw material for the production of drugs and fire extinguishing agents such as iodomethyl methionine (vitamin U), analgesics, antidotes, as well as the synthetic raw material of other organic compounds. It can also be used as a methylation reagent for the inspection of pyridine and microscope, and also as a fumigation disinfectant. In agricultural production, it is used as fungicide, plant parasitic nematode killer, soil pathogen killer, pre-sowing insecticide and herbicide. High-purity methyl iodide is often used in the pharmaceutical industry as an intermediate in organic synthesis. It is often used in the methylation reaction of alcohol, phenol, ketone, ester, carboxylic acid, amino compound, cyano compound, nitroalkane, sulfone, sulfoxide, imine and hydrazone; Iodomethane

Toxicity and application of high-purity iodomethane

Toxicity of high-purity methyl iodide:

 

 

  Animal experiments have confirmed that iodomethane mainly damages the central nervous system, stimulates the respiratory tract and skin, and also causes kidney damage. The acute inhalation experiment of high-purity methyl iodide showed that the median lethal concentration (LC50) was 1458 ppm (8165 mg/m3) when rats inhaled methyl iodide vapor for 1 hour; After 4 hours of inhalation, the absolute lethal concentration (LC100) was 1198 ppm (6709 mg/m3). When the LC50 was 691 ppm (3870 mg/m3), the poisoned rats developed wheezing, ataxia, decreased activity, runny nose, dyspnea, and red bubble secretion around the nose; At necropsy of the dead rats, blood stasis or hemorrhage in the pituitary gland, lungs, thymus gland and adrenal gland, flatulence and bleeding in the stomach and intestines can be seen with naked eyes; After inhalation of 32100 ppm (179760 mg/m3) for 15 min, the autopsy showed that the trachea and lungs of rats were severely eroded, accompanied by pulmonary edema and hemorrhage. It is also reported that most of the animals at autopsy have meningeal congestion and pulmonary congestion. The visceral microscopic examination of guinea pigs showed edema in brain tissue, turbid and swelling in liver and renal tubular cells, and infiltration of inflammatory cells in lung; After inhalation of 100 ppm (560 mg/m3) for 3 hours, the olfactory epithelium was slightly damaged, and the olfactory epithelium was significantly damaged at 6 hours, but the olfactory epithelium could be completely repaired after 2 weeks. It is reported that people may suffer from drowsiness, dizziness, gait instability and ataxia after inhaling high-purity methane-iodine vapor with a mass concentration of 95~143mg/m3 for several hours. The autopsy of the death case of acute iodomethane poisoning showed that the heart was pale, the heart muscle was loose, and all organs were "congested", including the brain, and some cerebral infarction. Microscopic examination of lung tissue showed bronchopneumonia and hemorrhage in the lung area, and lymphocytes and plasma cells infiltrated in multiple arterioles.
Application of high-purity methyl iodide:
Iodomethane is often used as the raw material for the production of drugs and fire extinguishing agents such as iodomethyl methionine (vitamin U), analgesics, antidotes, as well as the synthetic raw material of other organic compounds. It can also be used as a methylation reagent for the inspection of pyridine and microscope, and also as a fumigation disinfectant. In agricultural production, it is used as fungicide, plant parasitic nematode killer, soil pathogen killer, pre-sowing insecticide and herbicide. High-purity methyl iodide is often used in the pharmaceutical industry as an intermediate in organic synthesis. It is often used in the methylation reaction of alcohol, phenol, ketone, ester, carboxylic acid, amino compound, cyano compound, nitroalkane, sulfone, sulfoxide, imine and hydrazone; Methyl iodide is also a good initiator for the Grignard reaction, which is often used to initiate the Grignard reaction of inactive halides such as chlorinated aromatic hydrocarbons. It can be used as raw material of rhodium-iodine catalyst for methanol carbonylation.